Notre Dame/USC
This may not be the Notre Dame team of old, but 22 1/2 pts is alot to give up, especially in a rivalry game. USC has been hit or miss...sometimes blowing out quality opponents, and sometimes just squeking by with a victory. ND has been in every game untill the end, except Purdue. Both teams come into the game with a week of rest, and ND coming off a heartbreaker they'll want to avenge, while USC may have a letdown after blowing out Arizona. Also, ND plays well against ranked teams, 2-1 with their loss coming by 1 point to BC in the final minute of play. As a die hard ND fan, I'm alittle biased, but this still looks like a strong play to me.
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