How much +EV is needed?

[Calpeman]

I have a stack of 2600, the blinds are 300/150 no antes. Down to 350 players left top 110 places are paid, but prizes are very top loaded. (210x buy-in for 1st, 10x buy-in for 10th)

I am in mid position with AQ and can push all-in which I calculate has an +EV of about 250. Now if I think I am among the top 25% of the players is this a clear play or do I need more +EV to make this push.

Is there any general rule to how much +EV is needed to push all-in when you are down to about 10x BB. I really have no clue here so any help would be greatly appreciated.