What to do with those 6s

[Yads]

I'm always confused as to what to do with those hands with 6s in them, like 3456x, 24566, etc. I've been drawing one, but I wanted to know what posters here generally do with these hands. Should I be throwing that 6 away and drawing 2 if my opponent is drawing 1? What about if my opponent draws 2, should I just draw 1?