Fairly Common Situation

[TakeMeToTheRiver]

I find this decision to be very player dependent. Has he raised his drawing hand before? Would he have raised or called on the flop with a made flush? How good is his game? Does he know that he is effectively isolating you and would he do that with a drawing hand?

In many live games against a loose player who can be aggressive post-flop, a C/C, C/C is a good enough line and you will win often enough with TPMK. If a spade falls, you need to decide whether you can represent the big spade and get him to fold... again, very player and read dependent.