Big pot with TPTK

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If you are a good player but perhaps not the best player at the table, it seems like it's better to go with a medium stack around 50 bb instead. That way you still cover most of the poor players and you don't risk as much against the good players.

Thoughts?

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The nuts or close to it will stack the good players and the bad players. If you aren't buying in full because you are scared of the better players I think you should move down. Donks get big stacks sometimes too.

Adapting your play against players is a GOOD thing. Loosen up with position to isolate the donks and foldout the tighties; be (much) less likely to commit your stack with a hand like TPTK vs a tighty than a loosey. You already know how to do this, so don't buy in short.