"The Dreaded Ace"?

[12AX7]

Admitted, the question was lacking the detail folks around here generally want to see.

To be honest, I'd like to hear everything everyone has to say about it, so I can learn what to zero in on, in a manner that is efficient enough for multi-table play.

For example you point out number-of-opponents. Ok that's one parameter to consider. I'd think it's safe to say, more opponents staying to see the flop means greater chance one of them is holding the other ace.

In any event, I suspect there has to be a comprehensive line of analystical thought on it. Some set of principles applied at playing time.

And as you point up, there's going to be lots of situational "ifs".

And no doubt, pot size vrs. my redraw outs is a consideration too, for example.