What do 5/10+ Players Do Better than .5/1 or 1/2 players?

[Malachii]

What specifically do mid/high stakes players do better at 6max than winning low stakes players? I would say that a solid, winning $100 NL player plays good hands, plays them reasonably well postflop, and is generally able to keep himself out of tough spots. Yet if this $100 NL player attempted to play $5/10 6max against strong competition, he would probably get killed. What specifically do winning 5/10+ short handed players do better than a $100 6max players? What adjustments to these $100 NL players need to make as they move up in limits in order to be winning players?