SSHE "Hidden Outs"

[Jeoke]

Im curious how to apply the Hidden outs exercises in SSHE to my play. I understand how they work and everything but how do I use that concept while im playing? Obviously Its impossible to know exactly what your opponent has. Would It be better to guess the chance your oponent has a hand and then factor it in on that? Is that even a realistic thing to do?

Basically... when and how should I use this?