Are there any truly perfect synonyms?

[offTopic]

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regardless and irregardless

Vince and Smoothcall

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"irregardless" is not a word, "irrespective" is the word that you were thinking of.

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Let's not start that again.

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Indeed, I thought the inclusion of the second line would imply that I wasn't being serious in the first line, but apparently I needed to include a [img]/images/graemlins/grin.gif[/img] in the post body somewhere. Oh well...lesson learned.

[The Goober]

efficacious = effective

But really, virtually all synonyms are going to have at least slightly different connotations because the people who choose one word over the other. For instance, only wanks and people who work in the drug industry would say "efficacious"

[beckham9]

is there a difference between sarcastic and facetious? i seem to use them mostly interchangably.

[RocketManJames]

Here's my guess at a few that might make the cut:

1) INNATE / CONNATE
2) LISTLESS / LANGUID
3) PALE (adjective) / PALLID

But, the latter two pairs probably don't really work that well due to multiple definitions.

-RMJ