Phillips' wonder drug (also posted on WPT forum)

[Nilbud]

If you're going to criticize...

http://www.angryflower.com/itsits.gif

[just2ska]

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Paul-
I don't quite see the reason for your aggression towards me, but if you would like a discussion in detail, here you go...
Amphetamines exert there effect through a variety of mechanisms. For the sake of discussion we will use cocaine as an example. Cocaine exerts it effect through the mediation of neurotransmitters, primarily dopamine and nor-epinephrine. These neurotransmitters are metabolized by 3 mechanisms: 1)degradation by specific enzymes, 2)diffusion away from the neuro-synapse, and 3)pre synaptic re-uptake. Cocaine, and most amphetamines exert their effect by primarilay inhibiting pre-synaptic reuptake, thereby leaving and excess of dopamine and nor-epi at the synaptic junction. This in turn leads to an over stimulation of the alpha adregernic nervous system. The majority of the effects of these drugs (both good and bad) are related to this alpha adregernic effect. Provigil, on the other hand, is an enantiomer (a structural mirror like image) of a sympathetic-amine, therby making it an amphetamine like substance. The exact pharmacology of this drug is really unknown. It does not seem to directly effect either dopamine or nor-epi. It likely works by decreasing GABA related neurotransmission, an effect not demonstrated by the amphetamines, however this effect has not been clearly demonstrated either.
The majority of reported effects of this drug are in regards promoting wakefullness. Like I said earlier, it has been reported to produce euphoria. It has addictive properties also. It's current indications are for narcolepsy, and sleep disorders associated with shift work. It is used off-label for obstuctive sleep apnea/obesity-hypoventilation syndrome and ADHD.

As for my qualifications to discuss the subject, I am a physician and associate professor of Internal Medicine on the teaching faculty at 2 hospitals. I am double board certified in both internal medicine, as well as hospice and palliative care (of which there are currently only about 2000 physicians nationwide with this certification). I have been named the Teaching Attending of the year twice by the residencies that I teach at. I have had mutiple media apperances (TV, radio, and newspapers) for medical related issues. I have served as an expert witness in court multiple times. In addition to owning my own medical practice, I also serve as the medical director of a large university, overseeing the college health service. I have given multiple lectures specifically on the effects of amphetamines, so forgive me if I feel qualified to discuss the subject.
The one thing I am not qualified to discuss is what this drug is actually like to take, as I never have. You have apparently had experience with it. If you care to report your experience with the drug, I feel that is fine. However it is a personal experience, and this drug clearly is not something to be taken inappropriately. Your comments in the article may be interpreted by some as this drug being good for things it is not really indicated for. Only you can comment on what your indications for it were, and what additional effects you may have gotten from it, but I would hate to see people mis-interpreting your statement as an endorsement for its use for things like improving your chance in poker tourneys.

You have been very successful in life, and now so in poker also. Wether or not you wanted it, you are a public figure whom some people may look up to. Your comments in the article could be taken the wrong way by some. My response to the OP was only meant to provide some objective info and was not meant to upset anyone, including yourself.

I may suck at poker, but this stuff I know cold-

Good luck @ the big one, hope it works out for ya-

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looks like someone was trolling around on google... [img]/images/graemlins/wink.gif[/img]

[ddubois]

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Is it important to not have spelling and grammar errors on a resume?

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It is. And if he ever gives you his resume and asks for critism, then you can launch into your nit-picking fest with full vigor. But please do not waste our time correcting the typos of 2+2 posts, as if you were contributing some insight.

[Dov]

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But please do not waste our time correcting the typos of 2+2 posts, as if you were contributing some insight.

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Now THIS is insightful and enlightening.

Thanks.

[mdplayah]

Hey guys,

let's not destroy this guy. He is knowledgable.

I am somewhat versed on the topic of ADHD. and what i have seen lately is that a lot of the recent drugs have less addictive properties than the former ones (ritalin, adderal, concerta, etc.) Strattera is another which works in a non-traditional way to combat ADHD.


Anyway, i got massive access to medical journals so if you have a specific question post it and i'll try to provide you any pertinent studies and info.

peace y'all

[JimmyV]

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It is a generally accepted fact that highly skilled professionals have mastered the basic skills of reading, writing, and speaking. Most people who have a demonstrated deficit in one of these critical communication skills are not highly skilled professionals in anything, unless the language being used is not the mother tongue.

Do you really think that this is not true?


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Yes, this is not true.

[Nigel]

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It is a generally accepted fact that highly skilled professionals have mastered the basic skills of reading, writing, and speaking. Most people who have a demonstrated deficit in one of these critical communication skills are not highly skilled professionals in anything, unless the language being used is not the mother tongue.

Do you really think that this is not true?


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Yes, this is not true.

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So not true.

[ptmusic]

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It is a generally accepted fact that highly skilled professionals have mastered the basic skills of reading, writing, and speaking. Most people who have a demonstrated deficit in one of these critical communication skills are not highly skilled professionals in anything, unless the language being used is not the mother tongue.

Do you really think that this is not true?


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Yes, this is not true.

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So not true.

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Actually, I think what he said IS true, especially the second sentence, as long as you define "professional" as one of the traditional "professions" (e.g. doctor, lawyer, banker, etc.).

However, I believe his main point was that since the physician did not write well, he was probably not a physician at all. That is certainly not a logical conclusion; the doctor may be an exception to the rule.

-ptmusic

p.s. who cares.

[Dov]

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However, I believe his main point was that since the physician did not write well, he was probably not a physician at all. That is certainly not a logical conclusion; the doctor may be an exception to the rule.

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Actually, my point was a little deeper than that.

A few of my friends are highly recognized in their fields and one of the common traits seems to be pride in what they do. In other words, if they put their name on it, they make sure that it can't come back to bite them later, in any way, shape, or form.

They are detail oriented and meticulous.

Knowing who the competition is, I don't believe his claims based on his writing style. That is just me.

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p.s. who cares.

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Obviously you do. You bothered to respond.

Still, I understand your point. It seems like I am correct in my assessment, and even if I'm not, who cares what a doctor says that is at best too lazy to proof what he posts, and at worst not able to spell in the first place?

Exactly.

[creedofhubris]

I've used modafinil. It does what it's supposed to do, cut down your need to sleep. Didn't give me any speed-like symptoms either.

It's readily available from shady online pharmacies if you can't drum up a prescription.