Folding in a big pot when you know you're beat :P

[Aaron_]

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That's a good point I didn't even think of. Is the .25 worth the info gained on the CO player for future hands.

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I think it might - also, you lose a lot of image by fold this. If you fold with 78-to-1, you might encourage some river bluffs in future pots... not something I want to worry about.