Pre-flop Theory Question

A question: if playing 4 or more tables, amidst the almost constant change of players (many of whom have no footprint in either one's notes or in PT), how can these caveats--applying as they do to extremely confined and particular circumstances--be realistically applied? And if they cannot be realistically applied (and as I pose the question, it is obvious I harbor suspicions that they cannot), how can the recommendations that they support be implemented without risk to a bankroll?

The advice to play Axs, amidst other similar plays suggested in SSHE and HEFAP, is accompanied with warnings about the minimal edge such actions offer, under the best of circumstances. If one cannot, except under much less than ordinary circumstances, expect a positive result to said tactics, why bother with them at all?