Pokerstars 25c/50c Tight/Loose....?

I've been playing SSHE Loose starting hand chart on pokerstars 25c/50c... Recently, I switched to Tight chart and started losing loads of money... Hand sample is still very small so I don't think it will do any good posting stats, but I'm curious if anyone else is on Pokerstars 25c/50c area and has suggestions about preflop starting hands?

The games I play can be 9 headed one round, then next hand it will be heads up... and anywhere inbetween. So, I'm very confused with starting hands...