Deepish $1/$2, what to do with these Queens?

[SpaceAce]

Hero has been playing a touch aggressively, opening a lot of pots pre-flop and is not shy about raising his hands post-flop. Hero has folded to a couple of reraises post-flop but hasn't been put to the test often pre-flop. Villain is easily the other most aggressive player at the table and the only one who seems to play back at Hero. Hero suspects he has been pushed off the best hand once or twice already.

Hero has a fat stack of $400+ in this $1-$1-$2 blinds $50 buy-in game. Villain has > $200. Villain is losing in the game but doesn't seem tilty; he's bought back in several times and run his $50 back up. Villain has shown a great willingness to put his chips in the middle and has made several turn check-raises and other moves that are unusual in this game but every time he's had to show his cards, he's had a real hand. In other words, Villain has been very active but not stupid. Villain has not been caught very far out of line post-flop but has moved in pre-flop more than anyone else at the table.

On to the hand: a couple of people leave the game in between hands, bringing us down to five- or six-handed (I am not sure which). Villain has been yucking it up with his buddy who is losing a lot and just as the first card goes into the air after the other players have gotten up, Villain announces "Alright, the table is getting short-handed! Time to play more aggressive poker!" The cards are dealt, Villain's buddy raises to $10 UTG and Villain announces all-in, grabbing stacks of chips and putting them in the middle.

Hero looks down and finds Queens.

Villain's buddy is losing badly but he's reasonably tight pre-flop. Villain's buddy has a real hand to be raising UTG (let's say KQ or better) but does not look happy that Villain has gone over the top so Hero is not thinking Aces or Kings, here. Villain's buddy has ~$100. What's Hero's move?

SpaceAce