SKLANKSKY RELATION TO NL?

I've been reading a lot of Advanced Hold'em and a little of Small Stakes Holdem by Sklanksky and Malmuth lately but I just dont see how it applies to NL as much as it does to L.
Particularly on hand starting requirements, should I (generally of course) be playing the group hands to the dot as perscribed by the book? For instance I feel that playing 22 in any position (limping) has set value in the long run. Am I wrong?