On my way to search for the press release for this at Harrah's Web site (not there yet), I found this gem (dated October 20):
'National Heads-Up Poker Championship' Moves To Caesars Palace In New Deal
For those of you who don't have time to read the release, it doesn't look like there are many major changes other than the location. It will be held in March again, for broadcast by NBC in April & May over six episodes. Just like last time, it will be 64 players with a blind draw.
Two minor changes I noticed are the fact that NBC will be expanding their coverage from 8 to 10 hours, and that it will be exclusively broadcast on Sundays (some of the last competition was telecast on Saturdays).