Can one overcome a -EV game?

[pzhon]

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if a player was to buy-in comparatively small and not quit until he or the massive bankroll played a significant number of all-in hands against each other I believe that the massive buy-in would have an advantage. The concept of getting the best of it is in direct conflict with this way of thinking

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Please elaborate on what advantage you see that is more important than getting the best of it. It looks like a common, easily exploitable weakness that I (and other NL players) exploit regularly when a fish gets a big stack, but maybe you mean something else.