I need a lock for my suicide pool this week help!!

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Sportsbooks don't make a habit of offering easy wins. When you say you're betting a huge amount of your bankroll on one game, it is your responsibility to tell us why you're so sure if you want people to respect that decision. Because in general, betting 15-20% on a single game is a horrible idea.
And this is especially true considering that you're betting massively on Colts-Browns and Colts-Niners, so it seems like you're just planning to lay tons of points since you think the Colts are much better. In general, that is not a winning strategy.

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Ok ill give it a go. Last year i won big because i rode the colts and a eagles some on them slaughtering teams. But this was not in my decision at all this is my breakdown of the game. The jags, ravens and patriots are the 3 teams with any success at all in slowing down the colts, thus the colts averaging 19 points against them including playoffs and 39 points against any other team in the league. So I think people got swayed by the first 2 games of the colts.
I agree that there are very FEW bets that are great to bet even over the course of an entire season, but especially with the colts defense playing how it is, and the browns not having the personal to slow down the colts at all especially on the road, I just can't see a way of this being anything less of a blowout.
The way they lay the lines to have 50/50 on each side of course there are very few good lines to bet, but in the nfl theres always enough people on the other side for the spread not to get out line. I still would like to hear more replies about this, preferably about game specific things though.