What's Wrong With ATo?

I'm at 25k hands and I'm slightly down, so I was looking through my PT database to see if I could find any leaks in my game. One thing that stuck out is that ATo is my losingest hand by far. How do you guys typically play this hand? I thought my play was pretty standard, I usually open raise from any position, and raise in late position with 1-2 limpers. I'll typically fold when facing 2 bets. Postflop I'll play the same way I play most overcards, I'll fire on most flops and then play from there. I'm sorry for the vague post but I guess what I'm looking for is to see if anyone treats this hand differently than other typical raising hands. Should I be playing this hand tighter than most? Is 25k a large enough sample size to even start doing analyses like this? I'd appreciate any advice anyone has to offer.