What's your favorite (variation or made up) home game?

[TwoOuter]

I play with friends who don't like traditional games so we end up playing Baseball and Anaconda etc. over and over. It's incredibly boring when every other card is wild and every hand ends up with 5 of a kind beating a straight flush, but what can I do- they're my friends and I enjoy hanging out with them.

Any suggestions on different games of this ilk to break up the monotony? I'm not thinking of Guts or 7/27 or anything like that. Just some variations or made up games that are fun and require some skill.

Thanks for any feedback