Play this hand from the button?

[GrekeHaus]

What sort of flop are you hoping for with this hand?

1) A made flush--don't happen very often and when it does, you're not going to get paid off.

2) A flush draw--you'll only make it 1/3 of the time and if anybody else has something, you'll be paying a TON to make it. You might even have to fold if they push you out. If they don't have anything, then you might end up winning a small pot.

3) A pair of aces--nobody's paying you off unless they have an ace or a hand that can beat a pair of aces. If they have an ace, it will usually be a better ace. If it's a worse ace, you'll end up chopping a lot.

4) Trips/Two Pair--these are the only real flops you can hope for which might win you a big pot.

A5s is a hand that is destined to either win a small pot or lose a huge one. Since the only way you're winning a big pot with this is trips or two pair, you may as well be playing any two here.