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One of the reasons I quit drinking diet drinks was because a friend of mine was insisting that Aspartame had all sorts of side-effects that the "big food companies are keeping under wraps". I was waking up every morning sore from head to toe, I was feeling fatigued all the time, I kept getting headaches, etc... She pointed me towards some websites which listed my symptoms as those that typically result from "aspartame poisoning". Most of the websites seemed to be created by crackpots, but I told her that I was thinking of giving up caffeine anyway, so I would let her know if my symptoms went away after awhile.
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Again, The Straight Dope is your friend.