Who has the safest career stat lead??

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With dominant pitchers like Johnson and Clemens performing well into their 40s, I think Ryan's record is not completely safe, although it may last a while. Randy Johnson will probably not get there, but could very conceivably hit 5000, which shows you that it's touchable.

With teams in the NBA starting to run again and having success with it, a PG could come along to challenge Stockton's records as well. It's basically like 10 assts/gm for 15 full years. Someone will pass that eventually.

Like others said, pretty much all MLB wins/losses/CGs/SOs pitching records plus Gretzky's points will not be broken.