Multi-tabling strategy/on-screen logistics?

[KnickNut3]

All multi-tabling bonus whores--what do you find to be the best long-term way to multi-table on different sites without hurting your eyes or missing an action, etc.

I've got a 19 inch CRT and want to get to 4 tabling (and couldn't imagine 8-tabling). I have to start on interpoker, and I'm not sure how good it is about calling up the screens where action is necessary. Also IIRC, the windows that need action don't flash, and the timeout is pretty short, too. I tried 1600x1200 but it got to me pretty quickly as the cards are very small.

Just looking for suggestions, and if they differ for different programs.

Thanks.