When do you raise the flop?

[Spicymoose]

Assume you have AKs and you raise preflop. With a completely blank board, what situations do you bet the flop?

1. 2 opponents, you have the button
2. 4 opponents, you have the button
3. 2 opponents, you are first to act
4. 3 opponents, one left to act after you

I know there are no hard rules, but I'm curious as to what most (good) players would do. Does a mildly coordinated board change anything?

Thanks,
Spicymoose