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id expect your arms would get rather tired. unless you put the monitors below you with teh screen facing the ceiling. interesting idea.
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Your arms wont get tired.
I'm using a wacom tablet as a mouse. It's the A4 size which is pretty big. So I move my hand as mucch as when you use a touch screen.
Try it out, it's quite funny when you use it for the first time. When you're bored try your left hand. That's even funnier.
www.wacom.com