I fold them all in every situation. Even against a LAG, you're dominated most of the time.

The only exception is JTs which I might 3-bet or just cold call if the initial raiser is weak-tight post flop and/or the blinds tend to come in most of the time. I don't mind HU against weak tight and I wouldn't mind 4-way with JTs, so I'm good whichever way it goes.