I think most good poker players (not only 2+2ers) raise in this spot. The cutoff might be bluffing and the raise may cause weak Ax hands in early or mid pos, weak flush draws and gut shot str8 draws (like 87) to fold. If reraised by EP or bettor you can call and take one card off and hope for a 9 or a 7. If no improvement you could probably fold on turn or calling down if it's not too expensive. The pot has by then grown so big that the price is small to check out one opponent. He could be on a flush draw, a weaker hand than yours or a complete bluff. And you could still improve on the river.