Head to head play is about adjusting to the way your opponents play. If you opponent is a LAG adjust your starting hand requirements, dump your crap hands early and only get into a raising war when you think you have the best of it.

Try and get an understanding of how hand values change when h to h. For instance A2 hands go down in value and high only hands go up in value…

There are a lot of good posts on holdem h to h. Search for them and just apply what the recommend to Omaha.