I would take (and am taking in my pool) Pittsburgh. I think there is a chance Tampa gets picked off this week, for the following reasons:

(1) They are not that good.
(2) They are playing a back-up QB.
(3) They are traveling across country.
(4) They are playing on the road in an out-of-division game.

Am I saying that SF is going to win? No. Just that I think there are better risks to take.

Pittsburgh is playing against the worst offense in the history of the NFL, at home, in a division (very meaningful) game. I can't see not taking Pittsburgh here.