If these 2 guys are like a couple of guys at our home game--usually they bust out early, sometimes the build huge chips stacks, and in the side games they play "dealer's choice" games with wild cards and names like Mariah--then I would recommend a few things.
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If you have a choice, sit to their left so you can act after them.

If you are in a pot with them and have a hand better than just top pair, try to get heads up. Chances are they are betting aggressively with just top pair.If you can force out other players who might have you beat or have a better draw, you have a good chance of taking down a big pot heads up.

Other players are going to call them because everyone wants to take their money. If you can get in cheaply, try to see flops with connected cards or Axs, Kxs. The times you hit your flush or your straight should more than pay for the times you have to fold after the flop.

If you don't get the cards to take their money, just be patient. Someone is going to take their money, and then you can take the money from that player. It's not worth it to play looser in an attempt to get their money. Play good cards until they get knocked out, unless, as I said, you can get in cheaply with drawing hands.

The presence of a couple of gamblers at a game makes other players gamble more. That increases the risk for everyone. Let them knock themselves out, or others out, and then make your move (unless, of course, you have the cards).[/list]