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Don't isolate with that crap.

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At what point (which hands) do you start isolating?

If you are going to wait until you have KQ then you would be raising most of the time anyway and not just to isolate a known fish. You have to lower the standards a bit to call it an isolation raise.

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If I'm in MP, I definitely want something that has a chance should I get coldcallers behind me.
In LP QJo is fine. In MP, QJs would be a minimum for me.

If you do do this, and you get caught, you had better be prepared to play tight for the next 100 hands or so.