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I'm glad you posted this - we are coming to Vegas in Feb. for a conference which is at Mandalay Bay - but we love GVR and were thinking of staying there and driving to MB each morning (to get there before 8:00am) and coming back in the early evening or late afternoon. Would that be ridiculous/impossible?
We already have a room reserved in Thehotel.

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If you are driving from GVR to MB at around 7:30 AM it will probably take about 20-25 minutes depending on construction and accidents. By that I mean, if there is construction or accidents, it will be much longer. I would reccommend leaving earlier or staying on the strip.

This morning was my record, I made it to Wynn in 9 minutes from my place in Henderson. I averaged 105 MPH. This was at 4 AM.