[Bremen]

Assume 22 cards seen total, all his outs are live. So he'll draw out 1/3 of the time on the river. Assuming 6th and 7th are capped regardless you will win 8 bets on average while putting in 8. Given that his hand likely has some dead outs you'd actually be making money calling down.

I'm assuming he dosn't have a 4 flush here either for that matter... you really need to provide more info. But if as you say its a very large pot you almost certainly have odds to call down.