I found one that I think is really cool - but I can't speak to it's accuracy. I'd love to have some other people on this forum with a strong statistical background download it and give it a test-drive.
It's called Pokalyzer. I found it at:
www.any2cards.com when I was preparing to go out to Vegas for the WSOP.
It's $30 for a registered version. I've only used the free trial version (you can use it about 10 times for free before it locks you out). It has a great graphical interface and some cool features.
I'd be willing to pay for it - if a couple of people could confirm for me that the statistical analysis behind it is solid.
Thanks!