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I wouldn't think for more than a second before I called this against a PASSIVE player. Against a LAG there'd be no thought involved (well...maybe a little).

You have:
5 outs to two pair or trips
9 outs to the nut flush
a redraw to the nut straight

Yeah, some of these outs overlap so you don't really have 16 full outs, but I don't really want to do the math, and you get the point heh.

Last but not least, against a LAG you could very well be good with just the middle pair you already have.

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What if it was the same situation with bottom pair instead of middle pair?