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#1 Because the real junk hands can put you to a difficult decision.

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I think this is the main, if not sole, reason for not calling any 2. If you were all-in by calling the raise, you'd call it 100% of the time because your odds of winning justify it. We see this all the time in NL tournies where people are pot committed preflop.

The fact we're not all-in means it's post-flop that's causes the hand to be -EV enough to avoid calling any 2. Which brings me back to part of my original question. If we think we're better postflop, are these bad hands really so difficult to play than our post flop skill is more than negated by the cards?

I suppose the answer has to be yes, otherwise we'd play any two against the typical poor playing fish. It's just something that's interesting on a theoretical level (thus posted in the Theory forum).