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Is there any real major differece between playing 6-max and the 5-max games that are offered on paradise?

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Yes. There should be a noticeable difference in the hands you play at certain positions. Particularly I would reccommend opening more hands at the UTG+1 position in a 5 handed game as opposed to 6. Also, you can open at least a few more from UTG 5 handed but not too many more. Also, you should be a little more likely to reraise a raiser from the SB position 5 handed. I'd say BB and button position play fairly similar in both games, though subtle changes may be appropriate going from 6 players to 5.

Not making these adjustments will cost you more per hour than the bonus makes up for.