Impossible to answer without knowing one's personal preferences.

Gold Strike--hotel attached to casino. Very short walk to Horseshoe and Sheraton (as if there is any reason to go to Sheraton). Decent restaurants at GS and Sheraton. Very good restaurants at HS. GS rooms are very mediocre IMHO.

Grand--actually has three hotels. One is short walk to casino but not attached. The other two require a car or a ride on the fairly frequent free shuttles Grand provides. No restaurants in any of the hotels. Restaurants in the casino are a cut above GS's but not quite up to HS standards. Rooms at all Grand hotels are superior to those at GS IMHO. However, you do need a car to go to any of the other casinos unless you are willing to endure the aggravation of the low-cost shuttles to the other casinos.