I agree with most everything everyone has said.

If this was a limit hand and it was 3-bet or capped by the time it got back to you you have to fold. But not necessarily in NL.

Always pay attention to the stacks of the people in the hand. Do they have enough behind them to pay me off big if I hit? Plus, in this case, you have two villains seeing the flop with you.

LEVERAGE LEVERAGE LEVERAGE LEVERAGE.

holding 22 on a typical 27T flop or whatever, is HUGE. If just one of your opponents have an overpair like QQ or KK, you may be able to get his whole stack. And because two people called large raises PF, you can almost be certain that one of them holds a high PP.

Good luck. Remember, it's not about winning pots. It's about winning money. LEVERAGE!