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If you're backing TPTK with your stack every time you're going to lose your stack when he makes a hand.

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Agreed, but if he will fire with trash as often as he fires with a made hand (more often, because he always fires with trash, but will only pick up 2 pair or better every 5 flops or so), calling down with TPTK is +EV.

I may lose my stack when he has a hand, but I think he doubles me up more often than he stacks me. It's higher variance for sure, but playing LAGs is always higher variance. Another advantage is that if he is deep, once he doubles you up you can try to stack him again for twice as much with a real hand. Thoughts?