Betgo is correct in the fact that many players are often playing VERY scared/tight, avoiding confrontation as each player out = a step up the pay ladder. You can take advantage of this by actually playing for the win. Your fold equity on semi-bluffs goes way up. Its a stated rule of poker, if everyone is playing super-tight, you play aggressive and profit. However, often there WILL be players that are playing aggressive and trying to run the table. Re-stealing against them can be very profitable. For example, Folded to aggressive player in CO, he makes standard raise that he has made when folded to him in previous rounds, you have 89s on button, you shove it in. This is assuming stacks are similar and you have FE on him. If your stack is threatening to him, he is still going to have a much tighter range of hands that he is able to call you with than what he would be raising with in the first place, which could often be anything if blinds are scared/tight. If you are on the blind in this situation and button/SB fold, you can shove as well, and if he folds you get the added benefit of table presence. He will be more reluctant to attempt to steal your blind in the future, and it may get you a walk or two in future rounds. Plays like this are often very +EV.

Another thing is, if you are going into it as a big stack, don't be inclined to just piss chips away left and right. I often see a player drain his huge chiplead into an average stack (or just completely blow up) with several careless misplays. Aggression is good, blind aggression and pissing your stack away in poor spots is not.