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Clayton, do you think a typical $25PLO player lays down a T2 boat here to a half pot bet? Cause I don't.

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Once a typical PLO25 player fills, not much is moving him out of the pot, especially with one card to come and the chance to redraw to a better boat (however slim that chance is).

As to the original poster:

Betting out on the flop is fine. Getting called in two places should send out warning lights, even at this level, unless you have maniac reads on one/both opponents in the hand.

It is entirely possible that the first opponent is approaching this hand from a NLHE mentality, such that he is checking the nuts (or near nuts) no matter what. At least one of your opponents has the case 10. Filling on the turn, you need to bet out and see what is going on. A half pot bet should be sufficient. If you get called on the turn and checked to on the river, I check behind in most cases.