[Fallen Hero]

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they are very weak post flop.

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Then if you have position on them raise even more hands, isolate pf and outplay post flop.

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if his opponents are loose/passive type then raising preflop probably won't isolate.

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"I'm at this table with two guys that call raises with any two cards"

it will isolate those two opponents, if the whole table is loose/passive, that's a different situation.