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I think you should raise preflop.

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This is terrible. You'll almost never get it HU and even if you do your hand has some pretty bad reverse implied odds.

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With 1 limper in MP, I'm inclined to raise or fold. How often will it be raised behind you if you do limp in and then you're paying two bets to see the flop?

If you raise, as you say, most likely it won't be HU and a pair of 4's with overcards hitting in a large pot can't be good.