Preflop isolation is fine, especially if you know exactly why you are doing so.

Preflop should usually be jammed. If you think that the BB will call the bet and raise on the turn, I think that you can make a very strong argument for calling the flop and raising the turn.

The river is hilarious. It is read dependent, my guess is that they are not being too rational at this point in the night. 15/30 live is usually a very weak game with people frequently checking monsters on the river. They could have anything. 15/30 live isn't anywhere near the quality that you will find at 15/30 online.