1. It's a game of position. You make the bulk of your money in position.
2. Play obvious poker, NEVER NEVER NEVER try anything fancy with low-limit players, they don't understand. Remember, they think in terms of the strength of their hand and they cannot be bluffed. There are too many guys who will go too far with any piece of the board.
3. There are a lot of players who make very obvious moves like flopping a set, calling your flop continuation bet and then taking the betting lead on the turn or river. They will call large amounts of money to chase draws and then begin the betting when they complete their hand. So, if there's a flush posibility, you want to have the better flush. Or, if a straight is possible, you want the better straight. You must be aware of the hand they have and make sure your hand is better because you will be showing it down. Hence, tighten up.
3. Higher levels, well, when you get there, you'll see. The players are better so what you want to do is wait for a sucker to sit down and play him (you're playing the player, remember) the same way you play the suckers at the lower levels and you'll be taking his money.
If I understand your question properly, what adjustments need to be made, read Phil Gordon's new book or HOH 1, those books should give you an idea of playing and betting in NL hold 'em. Phil's starting hand charts are even available on his website.