I think it would be silly for a home game. Unless you did like a tournament structure like NBC did when they did theirs earlier this year.

Then at least the stakes are a little higher, and people would be playing for first and not just playing to end it.

Random heads up matchups would be pretty boring. It could be all over in 1-5 hands, or it could be some 30-60 minute grind out. But regardless, it limits the spectrum of skill involved, and IMO fun involved.