[Voltron87]

I always assumed the stuff Desmond was shooting himself with was an antidote or something similar to protect him from whatever "sickness" the people from the back of the plane were talking about.

Also, what has developed of that big monster/machine thing which killed the pilot waaay back in the beginning of season 1. Is that the same thing as the polar bear thing but bigger? I recall someone or something saying that it ate metal or something. It was big in the first 5 episodes but has faded away. Either way, the show had better start divulging real stuff soon, even just a little bit. I know a main character died in the last episode, but she was pretty useless plotwise and nothing about the island/science project was explained.