How I think about this:

With the preflop raise, most callers will have something like AQ,AJ,KQ,KJ... maybe even AT. Also, most people will call with pockets.

This is probably read-dependent. At my home game, I'd call this bet in a second against some players, and fold it without thinking against others.

Given no read, I'd probably go ahead and call this and expect AK/AQ. If they have 66 or 44, so be it.

As for A6 taking you out... screw him. Who the hell calls that raise w/ A6.